The first game I properly ran was a Witchcraft game. It didn’t go so well, didn’t even really go anywhere. I think we managed a couple of sessions at best before it fell apart – something that seems a common trait in my games when I’m feeling down.
The next game was a Vampire: the Requiem game as I recall – that actually went on for a while. The bit that stands out there was the ghouled cat called Twinky who ended up being better than most of the characters in a fight – when she could be bothered to take part. Rule 1 of ghouling – never let them know they can do it without you. Okay, so I was bending the rules with letting a cat do it independently, but it amused the players no end.
Then there was the old World of Darkness game that was actually a feint into a new World of Darkness game – the Apocalypse was changed by a cabal of mages who cast a ritual to remake the world in their image – setting themselves up as the Exarchs and removing everyone else’s memories. For some reason, the players could recall who they’d been, but had lost their abilities; they were just mortals stuck in an insane asylum. In the Old World, they’d been vampires and werewolves, and now they were just human. One of them found Malkovian in the asylum basement and got themselves ghouled – nowhere near as powerful as the vampire they’d once been, but still useful. With that, they managed to break out of the asylum and escape into the real world. Things didn’t go too far after that, but I thought the concept worked rather well.